List of Publications


43.    Swati Balakrishnan and Siddhartha P. Sarma

         Engineering Aromatic - Aromatic Interactions to Nucleate Folding in Intrinsically Disordered Regions of Proteins.

         Biochemistry, 2017,In press.


42.    Karuna Dixit, Ajay pande, Jayanti Pande, and Siddhartha P. Sarma

         Nuclear Magnetic Resonance Structure of a Major Lens Protein, Human γC-Crystallin: Role of the Dipole Moment in Protein Solubility.

         Biochemistry, 2016, 55, 3136-3149, DOI: 10.1021/acs.biochem.6b00359 .


41.    Kancherla Aswani Kumar, Srinu Meesala, Pooja Jorwal, Ramasamy Palanisamy, Sujit K. Sikdar, and Siddhartha P. Sarma

         A disulfide stabilized beta-sandwich defines the structure of a new cysteine framework M-superfamily conotoxin.

         ACS Chemical Biology, 2015, 10, 1847-1860, DOI: 10.1021/acschembio.5b00226.


40.     R. P. Rajesh.

         Novel M- and T-Superfamily conotoxins and contryphans from the vermivorous snail Conus figulinus.

         Journal of Peptide Science. 2015, 21, 29-39 .


39.    Vamsee V. A. Mallajosyula, Michael Citron, Francesca Ferrara, Xianghan Lu, Cheryl Callahan, Gwendolyn J. Heidecker, Siddhartha P.          Sarma, Jessica A. Flynn, Nigel J. Temperton, Xiaoping Liang, and Raghavan Varadarajan

         Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protection.

         Proceedings of the National Academy of Sciences USA, 2014, 111, E2514-E2523.


38.    Arijit Mukherjee, Karuna Dixit, Siddhartha P. Sarma and Gautam R. Desiraju

         Aniline–phenol recognition: from solution through supramolecular synthons to cocrystals

         International Union of Crystallography Journal, 2014, 1, 228-239.


37.    Tuhin Bhowmick, Soumitra Ghosh, Karuna Dixit, Varsha Ganesan, Udupi A. Ramagopal, Debayan Dey, Siddhartha P. Sarma,          Suryanarayanarao Ramakumar & Valakunja Nagaraja

         Targeting Mycobacterium tuberculosis nucleoid-associated protein HU with structure-based inhibitors

         Nature Communications, 5:4124, DOI: 10.1038/ncomms5124


36.     Arun Kumar Pandiakumar, Siddhartha P. Sarma, and Ashoka G. Samuelson.

         Mechanistic studies on the diazo transfer reaction.

         Tetrahedron Letters, 2014, 55, 2917 - 2920.


35.     Rustam Ali, Sanjeev Kumar, Hemalatha Balaram, and Siddhartha P. Sarma.

         Solution Nuclear Magnetic Resonance Structure of the GATase Subunit and Structural Basis of the Interaction between GATase and ATPPase          Subunits in a two-subunit-type GMPS from Methanocaldococcus jannaschii.

         Biochemistry, 2013, 52, 4308-4323.


34.     N. Megha Karanth and Siddhartha P. Sarma.

         The Coil-to-Helix Transition in IlvN Regulates the Allosteric Control of Escherichia coli Acetohydroxyacid Synthase I.

         Biochemistry, 2013, 52, 70-83.


33.     Shahul Hameed M. S. and Siddhartha P. Sarma.

         The Structure of the Thioredoxin–Triosephosphate Isomerase Complex Provides Insights into the Reversible Glutathione-Mediated Regulation of          Triosephosphate Isomerase.

         Biochemistry, 2012, 51, 533-544.


32.     Ganesan Senthil Kumar, Sanjeev Upadhyay, Mathew K. Mathew and Siddhartha P. Sarma.

         Solution structure of BTK-2, a novel hKv1.1 inhibiting scorpion toxin, from the eastern Indian scorpion Mesobuthus tamulus.

         Biochemica et Biophysica Acta: Proteins and Proteomics, 2011, 1814, 459-469.


31.     Javaid Yousuf Bhat, Roopa Venkatachala, Kavita Singh, Kallol Gupta, Siddhartha P. Sarma, and Balaram, H.

         Ammonia Channeling in Plasmodium falciparum GMP Synthetase: Investigation by NMR Spectroscopy and Biochemical Assays.

         Biochemistry, 2011, 50, 3346-3356.


30.     Rustam Ali, Sanjeev Kumar, Hemalatha Balaram and Siddhartha P. Sarma.

         1H, 13C, 15N assignment and secondary structure determination of glutamine amido transferase subunit of guanosine monophosphate synthetase          from Methanocaldococcus jannaschii.

         Biomolecular NMR Assignments, 2011, 1-4.


29.     Ganesan Senthil Kumar and Siddhartha P. Sarma.

         Cloning, overexpression and purification of a biosynthetically derived three disulfide scorpion toxin (BTK-2) from Mesobuthus tamulus.

         Protein Expression and Purification, 2010, 70, 137-142.


28.     N.Megha Karanth and Siddhartha P. Sarma.

         1H, 13C, 15N assignments of the dimeric regulatory subunit (ilvN) of the E. coli AHAS I.

         Biomolecular NMR Assignments, 2010, 4, 131-133.


27.     Kalyan Sundar Chakrabarti, Krishan Gopal Thakur, Balasubramanian Gopal and Siddhartha P. Sarma.

         X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate.

         FEBS Journal, 2010, 277, 697-712.


26.     N. Megha Karanth, Ashima Mitra and Siddhartha P. Sarma.

         Solution NMR studies of acetohydroxy acid synthetase I: Identification of the sites of inter-subunit interactions using multidimensional NMR           Methods.

         Journal of Molecular CatalysisB: Enzymatic, 2009, 61, 7-13.


25.     Ashima Mitra and Siddhartha P. Sarma.

         Escherichia coli ilvN interacts with the FAD binding domain of ilvB and activates the AHAS I enzyme.

         Biochemistry, 2008, 47, 1518-1531.


24.     Sharma, A. K., Sharma, S. K., Surolia, A., Surolia, N., and Siddhartha P. Sarma.

         Solution structures of conformationally equilibrium forms of holo-acyl carrier protein (PfACP) from Plasmodium falciparum provides insight into the          mechanism of activation of ACPs.

         Biochemistry, 2006, 45, 6904-6916.


23.     Kalyan Sundar Chakrabarti and Siddhartha P. Sarma.

         NMR assignment of 2H, 13C and 15N labeled amino-terminal domain of apo-pantothenate synthetase from E. coli.

         J Biomolecular NMR, 2006, 36, Suppl 1, 38.


22.     T. Prem Anand, Abdul Wajid Bhat, Yogesh S. Shouche, Upendra Roy, Jay Siddharth and Siddhartha P. Sarma.

         Antimicrobial activity of marine bacteria associated with sponges from the waters off the coast of South-East India.

         Microbiol. Res., 2006, 161, 252-262.


21.     Siddhartha P. Sarma, Ganesan Senthil Kumar, S. Sudarslal, Pratima Iengar, Palani Ramasamy, Sujit K. Sikdar, K. S. Krishnan and P. Balaram.

         Solution structure of delta-Am2766: a highly hydrophobic delta-conotoxin from Conus amadis that inhibits inactivation of neuronal voltage-gated          sodium channels.

         Chem. Biodivers, 2005, 2, 535-556.


20.     Shailendra Kumar Sharma, Rahul Modak, Shilpi Sharma, Alok Kumar Sharma, Siddhartha P. Sarma, Avadesha Surolia and Namita Surolia.

         A novel approach for over-expression, characterization and isotopic enrichment of a homogeneous species of acyl carrier protein from

         Plasmodium falciparum.

         Biochem Biophys Res Commun, 2005, 330, 1019-1026.


19.     Ashima Mitra, Kalyan Sundar Chakrabarti, Shahul Hameed, M. S., Kalyan V. Srinivas, Ganesan Senthil Kumar and Siddhartha P. Sarma.

         High level expression of peptides and proteins using cytochrome b5 as a fusion host.

         Protein Expr Purif., 2005, 41, 84-97.


18.     Ganesan Senthil Kumar†, Palani Ramasamy, Sujit K. Sikdar and Siddhartha P. Sarma.

         Overexpression, purification, and pharmacological activity of a biosynthetically derived Conopeptide.

         Biochem Biophys Res Commun., 2005, 335, 965-972.


17.     K. Hanume Gowd, V. Sabareesh, S. Sudarslal, Prathima Iengar, Benjamin Franklin, Antony Fernando, Kalyan Dewan, Mani Ramaswami,

         Siddhartha P. Sarma, Sujit K. Sikdar, P. Balaram and K. S. Krishnan.

         Novel Peptides of Therapeutic Promise from Indian Conidae.

         Annals of the Ne York Academy of Sciences, 2005, 1056, 462-473.


16.     Alok Kumar Sharma, Shailendra Kumar Sharma, Namita Surolia and Siddhartha P. Sarma.

         NMR assignment of the holo-ACP from malaria parasite Plasmodium falciparum.

         Journal of Biomolecular NMR, 2005, 32, 260.


15.     Vadim Gaponenko, Siddhartha P. Sarma, Amanda S. Altieri, David A. Horita, Jess Li and R. Andrew Byrd.

         Improving the accuracy of NMR structures of large proteins using pseudocontact shifts as long-range restraints.

         J. Biomolecular NMR, 2004, 28, 205-212.


14.     S. Sudarslal, G. Singaravadivelan, Palani Ramasamy, K. Ananda, Siddhartha P. Sarma†, Sujit K. Sikdar, K. S. Krishnan and P. Balaram.

         A novel 13 residue acyclic peptide from the marine snail, Conus monile, targets potassium Channels.

         Biochem Biophys Res Commun., 2004, 317, 682-688.


13.     S. Sudarslal, G. Singaravadivelan, Siddhartha P. Sarma, Sujit K. Sikdar, K. S. Krishnan and P. Balaram.

         Isolation and Characterization of Biologically Active Peptides from Indian Marine Snails,

         Proceedings of MBR 2004, 25-31.


12.     R. Padmashri, Kalyan Sundar Chakrabarti†, Dinakar Sahal, R. Mahalakshmi, Siddhartha P. Sarma and Sujit K. Sikdar

         Functional characterization of the pentapeptide QYNAD on rNav1.2 channels and its NMR Structure.

         Pflugers Arch., 2004, 447, 895-907.


11.     S. Sudarslal, S. Majumdar, Palani Ramasamy, Ritu Dhawan, Paromita P. Pal, Mani Ramaswami, Anil K. Lala, Siddhartha P. Sarma, K. S. Krishnan          and P. Balaram.

         Sodium channel modulating activity in a delta-conotoxin from an Indian marine snail.

         FEBS Lett., 2003, 553, 209-212.


10.     Rudresh, Rinku Jain, Varadhan Dani, Ashima Mitra†, Sarika Srivastava, Siddhartha P. Sarma, R. Varadarajan and Ramkumar, S.

         Structural consequences of replacement of an a - helical Pro residue in Escherichia Coli thioredoxin.

         Protein Engineering, 2002, 15, 627-633.


09.     Catherine A. Zwahlen, Kevin H. Gardner, Siddhartha P. Sarma, David A. Horita, R. Andrew Byrd and Lewis E. Kay

         An Improved Method for Measuring Methyl - Methyl NOEs in Methyl Protonated, Highly Deuterated Proteins.

         J. Am. Chem. Soc., 1998, 120, 7617 - 7625.


08.     Bindi Dangi, Siddhartha P. Sarma, Chun-Hua Yan, Debra L. Banville, and Ronald D. Guiles

         The Origin of Differences in the Physical Properties of the Equilibrium Forms of Cytochrome b5 Revealed through High-Resolution NMR Structures          and Backbone Dynamic Analyses.,

         Biochemistry, 1998, 37, 8289-8302.


07.     Holly A. Baden, Siddhartha P. Sarma, Rachel B. Kapust, R. Andrew Byrd and David S. Waugh.

         The Amino - Terminal Domain of STAT4 Forms a Stable, Symmetric Homodimer in Solution.

         J. Biol. Chem., 1998, 273, 17109 - 17114.


06.     Siddhartha P. Sarma, Russell J. DiGate, David B. Goodin, Cary J. Miller and Ronald D. Guiles.

         Effect of Axial Ligand Plane Orientation on Electronic and Electrochemical Properties Observed in Site Directed Mutants of Rat Cytochrome b5.

         Biochemistry, 1997, 36, 5658 - 5668.


05.     Siddhartha P. Sarma, Bindi Dangi, Chun-Hua Yan, Russell J. DiGate, Debra L. Banville and Ronald D. Guiles

         Characterization of a Site Directed Mutant of Cytochrome b5 Designed to Alter Axial Imidazole Ligand Plane Orientation.

         Biochemistry, 1997, 36, 5645 - 5657.


04.     Siddhartha P. Sarma, Russell J. DiGate, Debra L. Banville and Ronald D. Guiles.

         1H, 13C and 15N Assignments and Secondary Structure of Rat Ferricytochrome b5.

         J. Biomolecular NMR, 1996, 8, 171- 183.


02.     Ronald D. Guiles, Siddhartha P. Sarma, Russell J. DiGate, Debra L. Banville, Vladimir J. Basus, Irwin D. Kuntz and Lucy Waskell.

         Pseudocontact shifts used in the restraint of the solution structures of electron transfer complexes.

         Nature Structural Biology, 1996, 3, 333-339.


02.     Ronald D. Guiles, Valdimir J. Basus, Siddhartha P. Sarma, Swati Malpure, Kristine M. Fox, Irwin D. Kuntz and Lucy Waskell.

         Novel heteronuclear NMR methods of assignment transfer from a diamagnetic to a paramagnetic protein: application to rat cytochrome b5.

         Biochemistry, 1993, 32, 8329 - 8339.


01.     Siddhartha P.Sarma, K. S. Aithal, K. K. Srinivasan, A. L. Udupa, Vasant Kumar, D. R. Kulkarni and P. K. Rajagopal.

         Anti - Inflammatory and Wound Healing Activities of the Crude Alcoholic Extract and Flavonoids of Vitex Leucoxylon.

         Fitoterapia, 1990, 61, 263-265.