It was not meant to be here. That was just an accident ...
Master Shifu and others ...
Much of our understanding of biomolecular structure, and by inference, their physico-chemical properties, have been made possible by X-ray crystallographic studies of such molecules. The behavior of molecules in the solution state is often significantly different from that in the solid state. NMR spectroscopy is the method of choice for the structure determination of biomolecules in solution at atomic resolution. NMR spectroscopy finds practical applications in protein and nucleic acid structure determination, in studying protein - ligand interactions, in determining kinetic properties of enzymes, for elucidating catalytic mechanisms, in understanding metabolic fluxes in living cells and towards elucidating protein-folding pathways. The advent of multi-dimensional NMR methods has enabled the study of site-specific structural and physico-chemical properties of large, often complex molecules within a global context. Additionally, knowledge of structure has important implications for the design of new molecules that could function as pharmacological agents for therapeutic or diagnostic purposes. The research efforts in our laboratory focuses on, among others, structural properties of enzymes involved in metabolic pathways associated with amino acid, vitamin and nucleotide biosynthesis, disulfide rich peptide animal toxins, on intrinsically disordered proteins, aromatic interactions and their effects on protein stability.
"If the doors of perception were cleansed every thing would appear to man as it is, Infinite." - William Blake
"If officialdom in your neighbourhood does not appear to be transparent, get your eyes checked" - Siddhartha
There is no heaven, there is no hell
There are only the living and the dead
A few of the dead are living
Just as a few of the living are dead
The truth is, everyone is going to hurt you.
You just got to find the ones worth suffering for.
-Robert Nesta Marley