List of Publications

  1. Mihir Rami, Mohd Shafique, and Siddhartha P. Sarma Structural, functional, and mutational studies of a potent subtilisin inhibitor from Budgett’s frog, Lepidobatrachus laevis. Biochemistry, in press, .
  2. Aswani K. Kancherla and Siddhartha P Sarma Solution structures and thermodynamics of cis-trans X-Pro conformers of a novel single disulfide conopeptide. Indian Journal of Biochemistry & Biophysics, 60, 710-728, 2023.
  3. Tanaya Basu Roy and Siddhartha P Sarma Insights into the Transcriptional Regulation and Conformational Dynamics of the MazE9 Antitoxin in Mycobacterium tuberculosis. PROTEINS: Structure, Function, and Bioinformatics, 1  - 21 2023
  4. Khushboo Kumari and Siddhartha P Sarma Structural and mutational analysis of MazE6-operator DNA complex provide insights into autoregulation of toxin-antitoxin systems Communications Biology 5, 963 2022.
  5. Karuna Dixit, N. Megha Karanth, Smita Nair, Khushboo Kumari, Kalyan Sundar Chakrabarti, H. S. Savithri and Siddhartha P. Sarma. Aromatic interactions drive the coupled folding upon binding of the intrinsically disordered Sesbania mosaic virus VPg protein. Biochemistry, 59, 4663 - 4680, 2020
  6. Madhan Kumar Mohan, Nikita Abraham, Rajesh R P, Benjamin Franklin Jayaseelan, Lotten Ragnarsson, Richard J. Lewis, and Siddhartha P. Sarma. Structure and allosteric activity of a single-disulfide conopeptide from Conus zonatus at human α3β4 and α7 nicotinic acetylcholine receptors. Journal of Biological Chemistry, 295, 7096 - 7112, 2020.
  7. Nagarajan, Deepesh and Roy, Natasha and Kulkarni, Omkar and Nanajkar, Neha and Datey, Akshay and Ravichandran, Sathyabaarathi and Thakur, Chandrani and T., Sandeep and Aprameya, Indumathi V. and Siddhartha P. Sarma and Chakravortty, Dipshikha and Chandra, Nagasuma. Ω76: A designed antimicrobial peptide to combat carbapenem- and tigecycline-resistant Acinetobacter baumannii. Science Advances, 5, eaax1946, DOI: 10.1126/sciadv.aax1946, 2019.
  8. Akanksha Bansal, N. Megha Karanth, Borries Demeler, Hermann Schindelin and Siddhartha P. Sarma. Crystallographic structures of IlvN•Val / Ile complexes: Conformational selectivity for feedback inhibition of AHASs. Biochemistry, 58, 1992-2008, 2019.
  9. Chetna Baliga, Benjamin Selmke, Irina Worobiew, Peter Borbat, Siddhartha P Sarma, Wolfgang E. Trommer, Raghavan Varadrajan and Nilesh Aghera. CcdB at pH 4 Forms a Partially Unfolded State with a Dry Core. Biophysical Journal, 116, 807-817, 2019.
  10. Swati Balakrishnan and Siddhartha P Sarma. Engineering Aromatic - Aromatic Interactions to Nucleate Folding in Intrinsically Disordered Regions of Proteins. Biochemistry, 56, 4346 - 4359, 2017.
  11. Ajay Pande, Karuna Dixit, Jayanti Pande, Siddhartha P. Sarma. Solution structure of human GammaC crystallin. Investigative Ophthalmology & Visual Science, 55(12), 2016 .
  12. Karuna Dixit, Ajay Pande, Jayanti Pande, Siddhartha P. Sarma. Nuclear Magnetic Resonance structure of a major lens protein, Human γC-Crystallin: Role of dipole moment in protein solubility. Biochemistry, 55, 3136  - 3149, 2016.
  13. Aswani Kumar Kancherla, Sreenu Messala, Pooja Jorwal, Ramasamy Palanisamy, Sujit K Sikdar, and Siddhartha P. Sarma. A disulfide stabilized β - sandwich defines the structure of a new cysteine framework “M” - superfamily conotoxin. ACS Chemical Biology, 10, 1847-1860, 2015.
  14. Vamsee V. A. Mallajosyula, Michael Citron, Francesca Ferrara, Xianghan Lu, Cheryl Callahan, Gwendolyn J. Heidecker, Siddhartha P. Sarma, Jessica A. Flynn, Nigel J. Temperton, Xiaoping Liang, and Raghavan Varadarajan. Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protection. Proceedings of the National Academy of Sciences, USA., 111, E2514-E2523, 2014.
  15. Tuhin Bhowmick, Soumitra Ghosh, Karuna Dixit, Varsha Ganesan, Udupi A. Ramagopal, Debayan Dey, Siddhartha P. Sarma, Suryanarayanarao, R., and Nagaraja, V. Targeting Mycobacterium tuberculosis nucleoid-associated protein HU with structure-based inhibitors. Nature Communications, 5, 4124-4136, 2014.
  16. Arun Kumar Pandiakumar, Siddhartha P. Sarma, and Samuelson, A. G. Mechanistic studies on the diazo group transfer. Tetrahedron Letters, 55, 2917-2920, 2014.
  17. Arijit Mukherjee, Karuna Dixit, Siddhartha P. Sarma, and Desiraju, G. R. Aniline-phenol recognition: from solution to supramolecular synthons to cocrystals. International Union of Crystallography Journal, 1, 228-239, 2014.
  18. Srinu Meesala and Siddhartha P. Sarma Isolation of Actinomycin D from marine fauna associated bacteria. Planta Medica 79, PI69, DOI: 10.1055/s-0033-1352158 2013.
  19. Rustam Ali, Sanjeev Kumar, Hemalatha Balaram, and Siddhartha P. Sarma. Solution Nuclear Magnetic Resonance Structure of the GATase Subunit and Structural Basis of the Interaction between GATase and ATPPase Subunits in a two-subunit-type GMPS from Methanocaldococcus jannaschii. Biochemistry, 52, 4308-4323, 2013.
  20. N. Megha Karanth, and Siddhartha P. Sarma. The Coil-to-Helix Transition in IlvN Regulates the Allosteric Control of Escherichia coli Acetohydroxyacid Synthase I. Biochemistry, 52, 70-83, 2013.
  21. Shahul Hameed, M. S., and Siddhartha P. Sarma. The Structure of the Thioredoxin -Triosephosphate Isomerase Complex Provides Insights into the Reversible Glutathione-Mediated Regulation of Triosephosphate Isomerase. Biochemistry, 51, 533-544, 2012.
  22. Senthil Kumar, G., Upadhyay, S., Mathew, M. K., and Siddhartha P. Sarma. Solution structure of BTK-2, a novel hKv1.1 inhibiting scorpion toxin, from the eastern Indian scorpion Mesobuthus tamulus. Biochemica et Biophysica Acta: Proteins and Proteomics, 1814, 459-469, 2011.
  23. Rustam Ali, Sanjeev Kumar, Hemalatha Balaram, and Siddhartha P. Sarma. 1H, 13C, 15N assignment and secondary structure determination of glutamine amido transferase subunit of gaunosine monophosphate synthetase from Methanocaldococcus jannaschii. Biomolecular NMR Assignments, 6, 1-4, 2011.
  24. Javaid Yousuf Bhat, Roopa Venkatachala, Kavita Singh, Kallol Gupta, Siddhartha P. Sarma, and Hemalatha Balaram. Ammonia Channeling in Plasmodium falciparum GMP Synthetase: Investigation by NMR Spectroscopy and Biochemical Assays. Biochemistry, 50, 3346-3356, 2011.
  25. Senthil Kumar, G., and Siddhartha P. Sarma. Cloning, overexpression and purification of a biosynthetically derived three disulfide scorpion toxin (BTK-2) from Mesobuthus tamulus. Protein Expression and Purification, 70, 137-142, 2010.
  26. N. Megha Karanth, and Siddhartha P, Sarma. 1H, 13C, 15N assignments of the dimeric regulatory subunit (ilvN) of the E. coli AHAS I. Biomolecular NMR Assignments, 4, 131-133, 2010.
  27. Chakrabarti, K. S., Krishan Gopal, T., Gopal, B., and Siddhartha P. Sarma. X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate. FEBS Journal, 277, 697-712, 2010.
  28. N. Megha Karanth, Ashima Mitra, and Siddhartha P. Sarma. Solution NMR studies of acetohydroxy acid synthetase I: Identification of the sites of inter-subunit interactions using multidimensional NMR methods. Journal of Molecular CatalysisB: Enzymatic, 61, 7-13, 2009.
  29. Ashima Mitra, and Siddhartha P. Sarma. Escherichia coli ilvN interacts with the FAD binding domain of ilvB and activates the AHAS I enzyme. Biochemistry, 47, 1518-1531, 2008.
  30. Sharma, A. K., Sharma, S. K., Surolia, A., Surolia, N., and Siddhartha P. Sarma. Solution structures of conformationally equilibrium forms of holo-acyl carrier protein (PfACP) from Plasmodium falciparum provides insight into the mechanism of activation of ACPs. Biochemistry, 45, 6904-6916, 2006.
  31. Chakrabarti, K. S., and Siddhartha P. Sarma. NMR assignment of 2H, 13C and 15N labeled amino-terminal domain of apo-pantothenate synthetase from E. coli. Journal of Biomolecular NMR 36 Suppl. 1, 38, 2008.
  32. Anand, T. P., Bhat, A. W., Shouche, Y. S., Roy, U., Siddharth, J., and Siddhartha P. Sarma. Antimicrobial activity of marine bacteria associated with sponges from the waters off the coast of South East India. Microbiol. Res., 161, 252-262, 2006.
  33. Siddhartha P. Sarma, Kumar, G. S., Sudarslal, S., Iengar, P., Ramasamy, P., Sikdar, S. K., Krishnan, K. S., and Balaram, P. Solution structure of δ-Am2766: a highly hydrophobic δ-conotoxin from Conus amadis that inhibits inactivation of neuronal voltage-gated sodium channels. Chemistry & Biodiversity, 2, 535-556, 2005.
  34. Sharma, S. K., Modak, R., Sharma, S., Sharma, A. K., Siddhartha. P. Sarma, Surolia, A., and Surolia, N. A novel approach for over-expression, characterization, and isotopic enrichment of a homogeneous species of acyl carrier protein from Plasmodium falciparum. Biochemical and Biophysical Research Communications, 330, 1019-1026, 2005.
  35. Mitra, A., Chakrabarti, K. S., Shahul Hameed, M. S., Srinivas, K. V., Senthil Kumar, G., and Siddhartha P. Sarma. High level expression of peptides and proteins using cytochrome b5 as a fusion host. Protein Expression and Purification, 41, 84-97, 2005.
  36. Kumar, G. S., Ramasamy, P., Sikdar, S. K., and Siddhartha P. Sarma. Overexpression, purification, and pharmacological activity of a biosynthetically derived conopeptide. Biochemical and Biophysical Research Communications, 335, 965-972, 2005.
  37. K. Hanume Gowd, V. Sabareesh, S. Sudarslal, Prathima Iengar, Benjamin Franklin, Antony Fernando, Kalyan Dewan, Mani Ramaswami, Siddhartha P. Sarma, Sujit Sikdar, P. Balaram, and Krishnan, K. S. Novel Peptides of Therapeutic Promise from Indian Conidae. Annals of the New York Academy of Sciences, 1056, 462-473, 2005.
  38. Alok Kumar Sharma, Shailendra Kumar Sharma, Namita Surolia, and Siddhartha P. Sarma. NMR assignment of the holo-ACP from malaria parasite Plasmodium falciparum. Journal of Biomolecular NMR, 32, 260, 2005.
  39. Vadim Gaponenko, Siddhartha P. Sarma, Amanda S. Altieri, David A. Horita, Jess Li, and Byrd, R. A. Improving the accuracy of NMR structures of large proteins using pseudocontact shifts as long-range restraints. Journal of Biomolecular NMR, 28, 205-212, 2004.
  40. Sudarslal, S., Singaravadivelan, G., Ramasamy, P., Ananda, K., Siddhartha P. Sarma, Sikdar, S. K., Krishnan, K. S., and Balaram, P. A novel 13 residue acyclic peptide from the marine snail, Conus monile, targets potassium channels. Biochemical and Biophysical Research Communications, 317, 682-688, 2004.
  41. S. Sudarslal, G. Singaravadivelan, Siddhartha P. Sarma, S. K. Sikdar, K. S. Krishnan, and Balaram, P. Isolation and Characterization of Biologically Active Peptides from Indian Marine Snails. Proceedings of MBR 2004, 25-31, 2004.
  42. Padmashri, R., Chakrabarti, K. S., Sahal, D., Mahalakshmi, R., Siddhartha P. Sarma, and Sikdar, S. K. Functional characterization of the pentapeptide QYNAD on rNav1.2 channels and its NMR structure. Pflugers Arch - European Journal of Physiology, 447, 895-907, 2004.
  43. Sudarslal, S., Majumdar, S., Ramasamy, P., Dhawan, R., Pal, P. P., Ramaswami, M., Lala, A. K., Siddhartha P. Sarma, Krishnan, K. S., and Balaram, P. Sodium channel modulating activity in a δ -conotoxin from an Indian marine snail. FEBS Lett., 553, 209-212, 2003.
  44. Rudresh, Rinku Jain, Varadhan Dani, Ashima Mitra, Sarika Srivastava, Siddhartha P. Sarma, R. Varadarajan, and Ramkumar, S. Structural consequences of replacement of an α-helical Pro residue in Escherichia Coli thioredoxin. Protein Engineering, 15, 627-633, 2002.
  45. Zwahlen, C. A., Gardner, K. H., Siddhartha P. Sarma, Horita, D. H., Byrd, R. A., and Kay, L. E. An Improved Method for Measuring Methyl - Methyl NOEs in Methyl Protonated, Highly Deuterated Proteins. J. Am. Chem. Soc., 120, 7617 - 7625, 1998.
  46. Dangi, B., Siddhartha P. Sarma, Yan, C., Banville, D. L., and Guiles, R. D. The Origin of Differences in the Physical Properties of the Equilibrium Forms of Cytochrome b5 Revealed through High-Resolution NMR Structures and Backbone Dynamic Analyses. Biochemistry, 37, 8289-8302, 1998.
  47. Baden, H. A., Siddhartha P. Sarma, Kapust, R. B., Byrd, R. A., and Waugh, D. S. The Amino - Terminal Domain of STAT4 Forms a Stable, Symmetric Homodimer in Solution. J. Biological Chemistry, 273, 17109 - 17114, 1998.
  48. Siddhartha P. Sarma, DiGate, R. J., Goodin, D. B., Miller, C. J., and Guiles, R. D. Effect of Axial Ligand Plane Orientation on Electronic and Electrochemical Properties Observed in Site Directed Mutants of Rat Cytochrome b5. Biochemistry, 36, 5658 - 5668, 1997.
  49. Siddhartha P. Sarma, Dangi, B., Yan, C.-H., DiGate, R. J., Banville, D., and Guiles, R. D. Characterization of a Site Directed Mutant of Cytochrome b5 Designed to Alter Axial Imidazole Ligand Plane Orientation. Biochemistry, 36, 5645 - 5657, 1997.
  50. Siddhartha P. Sarma, DiGate, R. J., Banville, D., and Guiles, R. D. 1H, 13C and 15N Assignments and Secondary Structure of Rat Ferricytochrome b5. J. Biomolecular NMR, 8, 171- 183, 1996.
  51. Guiles, R. D., Siddhartha P. Sarma, DiGate, R. J., Banville, D., Basus, V. J., Kuntz, I. D., and Waskell, L. Pseudocontact shifts used in the restraint of the solution structures of electron transfer complexes. Nature Structural Biology, 3, 333-339, 1996.
  52. Guiles, R. D., Basus, V. J., Siddhartha P. Sarma, Malpure, S., Fox, K. M., Kuntz, I. D., and Waskell, L. Novel heteronuclear NMR methods of assignment transfer from a diamagnetic to a paramagnetic protein: application to rat cytochrome b5. Biochemistry, 32, 8329 - 8339, 1993.
  53. Siddhartha P. Sarma, Aithal, K. S., Srinivasan, K. K., Udupa, A. L., Kumar, V., Kulkarni, D. R., and Rajagopal, P. K. Anti - Inflammatory and Wound Healing Activities of the Crude Alcoholic Extract and Flavonoids of Vitex Leucoxylon. Fitoterapia, 61, 263-265, 1990.