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Course description

Welcome to the MB209 course page! This is the page related to the course on "Molecular and Cellular Neurophysiology" offered at the Molecular Biophysics Unit of the Indian Institute of Science, Bangalore.


Course Details

Code: MB 209

Title: Molecular and Cellular Neurophysiology

Credits: 3:1

Instructors: S. K. Sikdar and Rishikesh Narayanan

Duration and location: Aug–Dec 2017; MWF 11 AM; MBU seminar hall (Annex building)

First meeting: 7 August 2017, 11 AM, MBU seminar hall (Annex building)

Syllabus: Membrane components and structures; membrane transport; passive and active electrical properties of the membrane-ionic mechanisms of membrane and action potential; quantifying ionic hypothesis by voltage-clamp technique; Hodgkin Huxley formalism; structure-function aspects of voltage and chemically gated ionic channels; excitatory and inhibitory postsynaptic potentials; patch-clamp technique; recording and analysis of electrophysiological data; measurement of Ca concentrations in single cells; cell membrane capacitance and exocytosis, confocal microscopy. Synaptic plasticity: short-term and long-term potentiation and depression; mechanisms underlying synaptic plasticity; dendritic structure; dendritic ion channels; active properties of dendrites; dendritic spikes and backpropagating action potentials; intrinsic plasticity; mechanisms underlying intrinsic plasticity.


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